Download Chiral Sulfur Ligands: Asymmetric Catalysis (RSC Catalysis by Hélène Pellissier PDF

By Hélène Pellissier

The target of this ebook is to teach the excessive capability of chiral sulfur-containing ligands to advertise a number of uneven catalytic alterations. the real variety of stories seemed within the literature during the last 35 years frequently highlighted brilliant leads to phrases of potency and enantioselectivity, permitting entry to many biologically very important molecules, which sincerely demonstrates that those ligands can now be known as genuine rivals to the extra traditional phosphorus- or nitrogen-containing ligands. A key element of reference for post-graduate scholars, researchers and lecturers.

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In 1998, Pregosin et al. reported the synthesis of various S/N ligands with the nitrogen function arising from an oxazoline group and the S-coordinating atom from a thiosugar moiety. 31. The best result was obtained when the thiosugar moiety was substituted by a bulky substituent such as a pivaloyl group (97% ee). 30 Test reaction with cyclopenta[b]thiophene-alkyloxazoline ligands. 31 Test reaction with thioglucose-oxazoline ligands. In order to gain insight into the origin of the enantioselectivity of the process, these authors prepared a ligand in which the thioglucose function was replaced by a cyclohexyl ring.

12 N Pd = [Pd(C3H5)Cl]2 H 29 Test reaction with (S)-proline-derived sulfur-containing phosphine ligands. In 2001, Imamoto et al. 41 The preparation of BINAP reported in 1980 has marked a landmark in asymmetric catalysis and has illustrated the peculiar stereorecognitive properties inherent with the axially chiral 1,1 0 -binaphthalene framework. Since then, a great deal of work has been devoted to the preparation of binaphthalenetemplated ligands of related design. 13 Test reaction with monophospholanes with pendant t-BuS group.

55, it seemed that the position of the substituents at the heterocyclic skeleton of the ligand was important for the enantioselectivity. 55. This study has been more recently extended by Cozzi et al. 96 In the same context, Masson et al. 97 The bis(thiazolines) ligands were easily prepared in an overall yield of 75% through a five-step sequence by using dithioesters as sulfur sources and commercially available aminoalcohols. 56. In 1992, Pfaltz et al. 99 When applied as ligands in the test reaction, these ligands have proven to be as efficient as the corresponding oxazolines, and even in some cases more active and enantioselective.

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