Download Ciba Foundation Symposium 158 - Host-Guest Molecular PDF

Composed of contributions from specialists within the chemical and organic sciences, it explores host-guest molecular interactions resulting in the formation of molecular assemblies containing or extra species. fascinating purposes are rising during this box and it truly is anticipated that more suitable figuring out of the interactions in artificial host molecule complexes will result in a greater figuring out of the extra advanced organic structures. subject matters contain biomimetic chemistry, preorganization, self-assembly, template-directed synthesis, antibiotic binding to peptides and DNA, interactions among proteins and different molecules.


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Extra info for Ciba Foundation Symposium 158 - Host-Guest Molecular Interactions: From Chemistry to Biology

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It seemed to us that the first question requiring to be answered was whether or not a crown ether could serve as the head group for synthetic bilayer (vesicle) formation. This question was answered by the preparation (Gokel et a1 1987) and aggregation (Echegoyen et a1 1988) of aza-15-crown-5 attached to a steroid via a glycine res,idue. These compounds were found to aggregate into unilamellar vesicles of about 300 A diameter. They also exhibited 1-2070 volume entrapments and were generally similar to phosphatidylcholine vesicles.

Finally, D-amino acids are unknown in proteins but half of the residues in valinomycin have this stereochemistry. Indeed, the compound’s chirality can be represented as (D,D,L,L)3. The apparently too large size of valinomycin is not a problem: the compound folds into a ‘tennis ball seam’ arrangement that envelops K + threedimensionally. ; between the amide NH groups and the opposite amide carbonyl groups. In addition to holding the pre-binding conformation, this ties up the more polar amide carbonyl groups which would undoubtedly favour either Ca2+ or Na+ over K + .

In the steady-state method that we chose, a rate constant and kinetic order are determined by using 23Na NMR methods. 5). 5-1 h. Incubation was critical to the success of these studies. The kinetic order for each system could be obtained by varying the ionophore concentration. The cation transport ability of four compounds was assessed by the dynamic NMR method. Among them were gramicidin and the compound illustrated in 4. In addition to these, a cation carrier that corresponds to the centre of the molecule (CI2-< N18N > -CI2)and a triple ring structure lacking the external side-arms ( < 18N>-CI2--Cl2-N18>), were examined.

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