Download Dendritic Neurotransmitter Release by Mike Ludwig PDF

By Mike Ludwig

This article is going to spotlight the mechanisms and outcomes of dendritic transmitter liberate, with an emphasis at the mechanisms that generate such processing and how those can set off state-dependent plasticity within the processing. This quantity should be out of vast value, increasing the certainty of the spectrum of dendritic mechanisms for neural processing. it is going to show that dendritic liberate that most probably happens in the course of the mind is a key function within the regulate of data move in neural networks, via cross-talk and autorcontrol via paracine/autocrine mechanisms.

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2001, Selective targeting of newly synthesized Arc mRNA to active synapses requires NMDA receptor activation. Neuron 30: 227. , and Worley, P. , 2002, Local synthesis of proteins at synaptic sites on dendrites: role in synaptic plasticity and memory, Neurobiol. Learn. Mem. 78: 508. Stowell, J. , and Craig, A. , 1999, Axon/dendrite targeting of metabotropic glutamate receptors by their carboxy-terminal domains. Neuron IT. 525. Tang, S. , and Schuman, E. , 2002, Protein synthesis in the dendrite, Philos.

Armstrong (1995) provides a detailed review of the results achieved with this and other methods in the supraoptic nucleus. The majority show that most of the neurons are bipolar, though some have only one dendrite, and very few are multipolar (particularly in the retrochiasmatic (tuberal) part of the nucleus); branching in all types of dendrite is sparse. In all types, however, one dendrite passes ventrally to the ventral glial lamina, a second may pass dorsally. The dendrites are described as varicose, but few of the cells illustrated show dendritic dilatations of the size seen by electron microscopy (see below).

By contrast, it has been peptidergic neurons with much simpler dendritic architecture - in particular the magnocellular hypothalamic neurons which secrete vasopressin and oxytocin - which have been at the forefront of the study of the linked processes of dendritic secretion and dendritic plasticity. It seems almost certain, however, that what has been learned from the magnocellular system is widely applicable, since almost every immunocytochemical study of peptidergic neurons shows that the peptides which are known to be secreted from their axonal terminals are also distributed throughout their dendrites.

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